Carrier and Reproductive Risk
Secure Risk
By consultationPolygenic risk scoring for adults, for common complex conditions.
Polygenic risk scoring for adults, aggregating many common variants into a risk estimate.
- Specimen
- EDTA blood or saliva
- Methodology
- SNP genotyping + polygenic model
- Category
- Carrier and Reproductive Risk
Pricing is available through your BioBloom portal or on request.
Not used for embryo selection — polygenic screening of embryos is not permitted in the UK.
How it works
- 1
Order
Place the order through the BioBloom portal.
- 2
Sample
Collect the sample — EDTA blood or saliva.
- 3
Analysis
Laboratory analysis — SNP genotyping + polygenic model.
- 4
Report
Secure report delivered to your clinic through the portal.
What’s in the report
Polygenic risk estimate(s), provided as an adjunctive/emerging measure.
Research & evidence
Carrier screening established; adjuncts developingCarrier & reproductive risk
Expanded carrier screening is the ACMG-endorsed standard for identifying reproductive risk. Embryo polygenic scoring and immunogenetic adjuncts are active areas of research, best used within a specialist context.
Limitations: KIR-HLA-C is described by researchers in the field as too early for clinical intervention (Moffett 2016), and the ALIFE2 randomised trial found heparin did not improve live birth in inherited thrombophilia with recurrent loss. Embryo polygenic risk scoring has no established clinical utility and is not a routine test.
Read the research
